At doses previously mentioned the recommended dose selection, adverse reactions were comparable to All those thorough in Desk 1 below but frequently were being claimed additional commonly.
Even so, due to the fact higher plasma levels could raise the incidence of adverse reactions, a starting up dose of twenty five mg must be viewed as in more mature topics on account of the upper systemic exposure [see DOSAGE AND ADMINISTRATION].
However, in vitro studies with human platelets show that sildenafil potentiates the antiaggregatory impact of sodium nitroprusside (a nitric oxide donor). Furthermore, The mixture of heparin and VIAGRA had an additive effect on bleeding time inside the anesthetized rabbit, but this interaction has not been researched in people.
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VIAGRA isn't indicated for use in Gals. There isn't any suitable and perfectly-controlled research of sildenafil in pregnant women.
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This doc will not comprise all attainable Unwanted side effects and Many others may possibly occur. Test together with your health practitioner for sikik additional specifics of Negative effects.
The imply regular condition volume of distribution (Vss) for sildenafil is a hundred and five L, indicating distribution in the tissues. Sildenafil and its big circulating N-desmethyl metabolite are both of those approximately 96% bound to plasma proteins. Protein binding is independent of total drug concentrations.
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A starting off sahte viagra dose of twenty five mg needs to be regarded as in patients with any diploma of hepatic impairment [see DOSAGE AND ADMINISTRATION and Scientific PHARMACOLOGY].
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